GMP-grade nanoparticle targeted to nucleolin downregulates tumor molecular signature, blocking growth and invasion, at low systemic exposure

Small interfering RNA targeted to secretory clusterin blocks tumor growth, motility, and invasion in breast cancer.

Clusterin/apolipoprotein J (Clu) is a ubiquitously expressed secreted heterodimeric glycoprotein that is implicated in several physiological processes. It has been reported that the elevated level of secreted clusterin (sClu) protein is associated with poor survival in breast cancer patients and can induce metastasis in rodent models. In this study, we investigated the effects of sClu inhibitio...

Blocking tumor growth, invasion, and metastasis by maspin in a syngeneic breast cancer model.

Maspin is a unique serine protease inhibitor of which the down-regulation is associated with the development of breast cancers. In vitro, recombinant maspin inhibits tumor cell migration and invasion. Overexpression of maspin in transgenic mice is protective against tumor progression. Additionally, maspin acts as an angiogenesis inhibitor in rat cornea model and in a xenograft tumor model. To a...

Targeted therapy in pediatric low-grade glioma.

Collectively, pediatric low-grade gliomas account for most brain tumors reported in children. Surgery is typically curable for operable lesions. However, more effective therapies are required for inaccessible tumors, both to overcome refractory disease and to minimize the toxicity associated with conventional adjuvant chemotherapy and radiotherapy regimens. Recent years have witnessed rapid imp...

At the crossroad of physiological and pathological invasion: The role of Progesterone-Induced Blocking Factor in trophoblast and tumor invasion

A nucleolin-targeted multimodal nanoparticle imaging probe for tracking cancer cells using an aptamer.

UNLABELLED The recent advances in molecular imaging techniques, using cancer-targeting nanoparticle probes, provide noninvasive tracking information on cancer cells in living subjects. Here, we report a multimodal cancer-targeted imaging system capable of concurrent fluorescence imaging, radionuclide imaging, and MRI in vivo. METHODS A cobalt-ferrite nanoparticle surrounded by fluorescent rho...